The total percentage of PTPN6 alterations in cancer amounts at 2.7% (with amplifications and mutations as the most frequent ones) whereas uterine carcinosarcoma (7.01%), testicular germ cell cancer (6.04%), ovarian cancer (5.82%), and melanoma (5.18%) show the highest frequency of PTPN6 genomic alterations. The gene discussed is PTPN6; the disease is melanoma.