In hematopoietic cancers, besides the hypermethylation, enrichment of histone markers of silencing (e.g., trimethylation at lysine 9 of histone H3, trimethylation at lysine 27 of histone H3 and acetylation at lysine 9 of histone H3) is detected at the PTPN6 promoter (69), thus implying that also these histone modifications intervene in PTPN6 expression regulation. The gene discussed is PTPN6; the disease is hematopoietic and lymphoid cell neoplasm.