Another study with breast cancer cell lines has indicated that YAP/TAZ reprograms metabolism of breast cancer cells to glutamine-dependent one by inducing glutamic-oxaloacetic transaminase (GOT1) and phosphoserine aminotransferase (PSAT1), which are the key enzymes to convert glutamate to α-ketoglutarate (α-KG) (156). The gene discussed is WWTR1; the disease is breast carcinoma.