To develop an m6A-related gene signature for prognosis prediction of NPC, the univariate Cox regression analysis was used to reveal the relationship between four m6A genes (METTL3, YTHDF3, IGF2BP1, and IGF2BP2) and the PFS of NPC patients in the GSE102349 datasets. The gene discussed is METTL3; the disease is nasopharyngeal carcinoma.