Moreover, two genes (METTL3 and YTHDC1) were downregulated and seven genes (YTHDF1, YTHDF2, METTL5, YTHDF3, IGF2BP2, IGF2BP3, and IGF2BP1) were upregulated in NPC tissue compared to normal tissue in GSE53819. The gene discussed is METTL5; the disease is nasopharyngeal carcinoma.