GATA6 and lung adenocarcinoma: We then generated doxycycline (DOX)-inducible expression of GATA6 for A549 cells (lung adenocarcinoma cell line), a cell line with low expression of GATA6 (referred to as A549i) (Figure 1E) and found that ectopic expression of GATA6 significantly slowed down the growth rate and inhibited the ability of A549i to form colonies in 2-D plates (Figures 1F–H).