Crosslinking of UBE2N and Ub catalyzed by MavC leads to the inhibition of the UBE2N‐mediated NF‐κB activation, which is essential in the early infection, whereas the deubiquitinase activity of MvcA restores the activity of UBE2N to allow the recovery of host signaling pathways in the later phases of infection when the bacteria have already successfully evaded host detection. The gene discussed is NFKB1; the disease is infection.