NFKB1 and bacterial infectious disease: As a key checkpoint for activation of the NF‐κB pathway, UBE2N appears to be a common target of such cellular subversion as bacterial infection; it can be regulated by diverse mechanisms such as deamidation and ISGylation.[3,19] MavC and MvcA regulate the activity of UBE2N in spatial and temporal manner via their opposite enzymatic activities.