Since prior in vivo studies showed that ECM remodeling is mediated by matrix metalloproteinase (MMP),[13, 25, 26, 27] MMP inhibitors were studied extensively to stop or slow down aneurysm and atherosclerosis progression with limited success.[28] We, therefore, investigated the roles of various counterbalancing MMPs and TIMPs in adjusting the collagen III/I ratio and the collagen‐to‐elastin balance in this model. This evidence concerns the gene ELN and aneurysm.