TFRC and Iron deficiency anemia: Iron deficiency has been associated with mitochondrial dysfunction due to the role that iron plays in the biogenesis of mitochondrial Fe‐S clusters and electron transport chain subunits.[24] Given that both beige and brown adipocytes contain large numbers of mitochondria for energy expenditure and thermogenesis, it is reasonable to speculate that the development of beige/brown adipocytes requires Tfr1 in order to take in sufficient amounts of iron to maintain normal mitochondrial function.