In the present study, the lack of pulmonary fibrosis despite the formation of granulomas could be explained by a long‐lasting Th1 polarized immune response (combined with an inhibition of pro‐fibrotic Th2 immune response, as mentioned above), and an elevated level of interferons (i.e., IFN‐β (ELISA measured, significant at 7 days after l‐GO exposure) or IFN‐γ (revealed by analysis of RNA sequencing)), especially after l‐GO exposure. This evidence concerns the gene IFNB1 and Granuloma.