CDH1 and Granuloma: Indeed, a recent study suggested that granuloma macrophages and pre‐malignant epithelial cells may share common mechanisms of adaptation to chronic genotoxic stress.[60] In tuberculosis, granuloma macrophages are also known to adopt an epithelioid appearance, and to undergo reprogramming events involving E‐cadherin‐dependent formation of epithelial‐like cell‐cell junctions.[43] Thus, one should be cautious concluding that the present transcriptomics results point toward a definite pro‐carcinogenic potential of l‐GO.