directly injected DNA plasmid encoding Cas9 and sgRNAs that target p53 and Pten (two tumor suppressor genes) into mouse liver and induced tumor growth.[38] Meanwhile, Ventura and co‐workers demonstrated the feasibility of adapting the CRISPR/Cas9 system to model large oncogenic chromosomal rearrangements in wild‐type mice via an Eml4‐Alk inversion through the delivery of an adenovirus encoding Cas9 and two sgRNAs.[39]. Here, PTEN is linked to neoplasm.