Interestingly, metformin selectively led to the nearly twofold increase of IL‐8, which is critical during bacterial infections.[41] While, there was no effect on the production of TNF‐α, IL‐1β and IFN‐γ (Figure 5C), implying that metformin might recruit the neutrophils to the sites of infections. This evidence concerns the gene CXCL8 and bacterial infectious disease.