MDM2 and nuclear factor of activated T-cell 1 (NFAT1) dual inhibitor induces MDM2 autoubiquitination and degradation, and represses NFAT1-mediated MDM2 transcription, which can inhibit the growth and metastasis of HCC cells in vitro and in vivo152. This evidence concerns the gene NFATC2 and hepatocellular carcinoma.