Protein regulator of cytokinesis 1 (PRC1) can promote cytokinesis of HCC cells and induce HCC cell desensitization to taxol by inhibiting p53/p21 or p53/p14ARF activation163; SIRT7 can cause doxorubicin resistance by interacting and inducing deacetylation of p53, and thereby reducing affinity for the NOXA promoter and its transcription164. The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.