TP53 and cancer: Such proapoptotic BCL‐2 family proteins [BCL‐2‐associated X protein (BAX), NOXA, and p53-upregulated modulator of apoptosis (PUMA)] can be transcriptionally activated10; metabolic enzymes [p53-induced glycolysis and apoptosis regulator (TIGAR) and glucose transporters] that contributed to cancer metabolic switch can be inhibited11.