Protein regulator of cytokinesis 1 (PRC1) can promote cytokinesis of HCC cells and induce HCC cell desensitization to taxol by inhibiting p53/p21 or p53/p14ARF activation163; SIRT7 can cause doxorubicin resistance by interacting and inducing deacetylation of p53, and thereby reducing affinity for the NOXA promoter and its transcription164. This evidence concerns the gene SIRT7 and hepatocellular carcinoma.