TP53 and hepatocellular carcinoma: Recently, Heng Wu et al.117 proposed that microRNA-21 might be a potential link between NAFLD and HCC; they considered that microRNA-21 overexpression, which was mediated by lipid accumulation of hepatocytes, can enhance carcinogenesis-related protein expression (CCNB1, CCND1, and SREBP1C) by inhibiting p53 expression, because the target of microRNA-21 (HBP1) is also a transcriptional activator of p53.