Debanjan Dhar et al.122 proposed that the link of HCC initiation (differentiated hepatocytes converted into HcPC) and MDM2–p53 axis dysfunction is provided by CD44, which is a hyaluronic acid receptor whose expression is rapidly induced in carcinogen-exposed hepatocytes in a STAT3-dependent manner. The gene discussed is TP53; the disease is hepatocellular carcinoma.