In addition, RNA-binding motif protein 38 (RBM38), glycogen synthase 2 (GYS2), and sirtuin3 have been reported to exert anti-HCC roles via stabilizing the MDM2–p53 loop function by inhibiting MDM2 and restoring wtp53 expression and/or slowing p53 degradation58,161,162. This evidence concerns the gene MDM2 and hepatocellular carcinoma.