NLRP3 and metabolic dysfunction-associated steatotic liver disease: Also, in a more recent study, a group of NAFLD surgical specimens was studied observing an accumulation of FC and oxidized low-density lipoprotein in the portal vein and the hepatic sinusoidal parenchyma in the form of cholesterol crystals, related to the activation of NOD-like receptor family pyrin domain containing protein 3 (NLRP3) inflammasome promoting inflammation, HSCs activation and a characteristic chicken-wire fibrosis35.