TNF and metabolic dysfunction-associated steatohepatitis: The first cholesterol-induced NASH hypothesis was proposed more than 10 years ago by suggesting that mitochondrial FC loading changed the fluidity of the mitochondrial membranes, leading to the oxidation of mitochondrial glutathione, and sensitized hepatocytes to tumor necrosis factor and Fas-dependent death signaling via mitochondrial glutathione depletion, exacerbating NASH30.