KDM6A and glioblastoma: In addition, another histone demethylase family protein, KDM6A/B, plays a key role in glioblastoma stem cell (GSC) plasticity, in which tolerant GSCs up-regulate KDM6A/B and redistribute histone H3 lysine 27 trimethylation (H3K27me3) on repressive chromatins8.