MLPH and Griscelli syndrome: Melanosome capturing by actin filaments and subsequent actin-based melanosome transport are regulated by a tripartite protein complex, Rab27A–Slac2-a (also known as melanophilin [MLPH])–myosin Va, and abnormalities in the function of this complex cause Griscelli syndrome, a rare autosomal recessive hypopigmentation disease2,38.