To investigate the increased occurrence of pancreatic cancer in smokers, a range of pancreatic cancer cell lines were used (CD18/HPAF, Capan1 and FG/Colo357) as well as non-cancerous human pancreatic ductal epithelial cells and exposed to a range of nicotine concentrations (0.1 μM, 1 μM and 5 μM). Here, ITGB2 is linked to pancreatic neoplasm.