In human NB tissue, SOX10 expression pattern could be divided into neuroblasts-specific (hereinafter referred to as “Pattern I”) 3.5% of NB (4 patients); Schwannian stroma-restricted (hereinafter referred to as “Pattern II”) 45.2% (52 patients) and SOX10-negative, 51.3% (59 patients) (Figure 1H and Supplementary Figure 2D). Here, SOX10 is linked to neuroblastoma.