The contrasting phenotypes of SUSD2 in breast and other epithelial cancers may be explained by differences in metastasis mechanisms [29, 30], microenvironments, subcellular localizations of SUSD2, or splice-form variants of SUSD2. However, the results from this study suggest that SUSD2 acts as a tumor suppressor through the inhibition of late-stage metastasis in HGSOC. The gene discussed is SUSD2; the disease is neoplasm.