Fuzheng-Qingjie granules can not only induce mitochondria-mediated apoptosis in HepG2 hepatoma cells in vitro but also increase the number of CD4+ T lymphocytes, NK cells, and ratio of CD4+/CD8+ T cells in the peripheral blood of H22 subcutaneous tumor-bearing mice [54]. Here, CD8A is linked to hepatocellular carcinoma.