These have shown agonistic action with high binding affinity for ERα (highly expressed in cancer-sensitive tissues) [49] and ERβ; isoflavones retain selective affinity for ERβ, which is present in tissues requiring certain stimulation by estrogen to function normally (e.g., bone tissue, bone marrow, adipose, brain, kidney, endothelial cells, and liver) [50]. The gene discussed is ESR2; the disease is cancer.