Moreover, SMP and one of the main components, berberine, were confirmed to regulate the blood lipids, increase the level of high-density lipoprotein, which is thought to improve rheumatism and benefit the cardio-cerebrovascular disease in terms of the common view that patients with rheumatoid arthritis are at increased risk of cardiovascular disease [38–40]. Here, FAM53B is linked to rheumatoid arthritis.