TP53 and lung cancer: Luteolin is a flavonoid which has been shown to have antitumor effects on lung cancer via degradating EGFR mutation [37], suppressing Raf and PI3K activities [38], regulating ROS-mediated multiple cell signaling pathways [39], activating the p53 pathway [40], a p38/ROS/caspase cascade [41], and MEK/ERK signaling pathway [42].