The results indicated that the KEGG pathways of the top targets are mainly involved in the thyroid cancer, small-cell lung cancer, ABC transporter, bile secretion, sphingolipid signalling, amyotrophic lateral sclerosis (ALS), hepatitis B, prostate cancer, bladder cancer, NF-κB signalling, toll-like receptor signalling, IL-17 signalling, TNF signalling, AGE-RAGE signalling in diabetic complications, leishmaniasis, African trypanosomiasis, malaria, rheumatoid arthritis, graft-versus-host disease, and fluid shear stress and atherosclerotic pathways. The gene discussed is TNF; the disease is rheumatoid arthritis.