To investigate the biological function of lnc-HSD17B11-1:1 in CRC cells, we first detected lnc-HSD17B11-1:1 expression levels in CRC cell lines and found high expression in cancer cell lines in comparison with colorectal normal one NCM460, especially in HCT116 and SW480 (Figure 2A). Here, HSD17B11 is linked to colorectal carcinoma.