Although how exactly ARID5B is connected to ALL remains unknown, it is safe to assume that it may be involved in epigenetic regulation of gene expression in hematopoietic stem cells and early lymphoid progenitors like other AT-rich DNA-binding proteins (Webb et al., 2011; Yokota and Kanakura, 2014). This evidence concerns the gene ARID5B and acute lymphoblastic leukemia.