RUNX1 and acute lymphoblastic leukemia: It has been reported, for example, 80% of infant ALL cases, diagnosed in children less than 1 year of age, have an MLL-r, while approximately 35% of cases with B-ALL aged 1–9 years are diagnosed with the hyperdiploid subtype and another 30% are diagnosed with ETV6-RUNX1 fusions (Hunger and Mullighan, 2015).