The data showed a modest but significant increase in F-ara-A (the nucleoside pro-drug of fludarabine) IC50 attributed to the overexpression of ARID5B, partly through regulation of mitogen-activated protein kinases (MAPK) pathway, whose inhibition results in fludarabine resistance in CLL (Pandzic et al., 2016). Here, ARID5B is linked to B-cell chronic lymphocytic leukemia.