Indeed, Besides Studd et al. (2017) identified a potential causal variant (rs7090445) for hyperdiploidy ALL risk at ARID5B locus which localized to intron three of ARID5B, and found its risk allele served to reduce enhancer activity of ARID5B in leukemic blasts (Studd et al., 2017). The gene discussed is ARID5B; the disease is acute lymphoblastic leukemia.