DNAH8 and early-onset autosomal dominant Alzheimer disease: Module 2 included 27 nodes and 84 PPI pairs (Figure 4B), and KEGG analysis showed that these genes were enriched in energy metabolism associated pathways (oxidative phosphorylation, citrate cycle, and carbon metabolism), and neurodevelopmental disorders (Parkinson’s disease, Huntington’s disease, and Alzheimer’s disease), and GO terms were primarily in cellular respiration, organelle localization, oxidoreductase complex, mitochondrial protein complex, oxidoreductase activity, and ATPase activity (Figure 4E).