EGFR and lung cancer: Zhang et al. (2017) detected that SPP1 was highly expressed in tumor-associated macrophages (TAMs) and LUAD tissues, and SPP1 played a role in lung cancer escape and mediating macrophage polarization. Wang et al. (2019) detected that inhibiting the SPP1 expression in lung cancer may overcome the resistance of second-generation EGFR TKI, and the expression of SPP1 may lead to increased resistance of lung cancer.