For example, mice with experimental autoimmune encephalomyelitis (EAE) injected with DCs treated with Ts-MLES showed significantly reduced EAE severity, an outcome associated with downregulation of Th1/Th17 responses, boosting of regulatory T cells and increased secretion of regulatory IL-10 and TGF-β cytokines (36). The gene discussed is TGFB1; the disease is experimental autoimmune encephalomyelitis.