F8 and hemophilia A: It has been shown that ectopic expression of factor VIII (FVIII) in platelets directed by either the glycoprotein (GP) Ib or the GPIIb (αIIb) promoter can lead to the storage of FVIII in platelet α-granules and that platelet-derived FVIII can improve hemostasis in hemophilia A mice even in the presence of anti-FVIII inhibitory antibodies (referred to as inhibitors) (13, 15, 17, 21).