It was also found that GPER is capable to affect nuclear factor-κB (NF-κB) and Notch as well as Hippo signaling, where the membrane-bound estrogen receptor regulates phosphorylation of crucial proteins through Gαq−11 action, enhancing the proliferation and migration potential of breast cancer cells (11, 13, 14). Here, ESR1 is linked to breast carcinoma.