Contradictory evidence is present in the gray literature, suggesting that EVs isolated from human adipose MSCs enclose pro-inflammatory cargo (miR-126 and proteins IFN-γ, IL-1, IL-6, and IL-17) and increase expression of pro-inflammatory cytokines in human peripheral mononuclear blood cells from T1DM and T2DM donors (43). This evidence concerns the gene IL1B and type 1 diabetes mellitus.