Conceivably, its specificity for neuronal damage might distinguish plasma NF-L from other blood-based biomarkers with predictive value for stroke outcome reflecting other biological processes, such as copeptin (34), brain natriuretic peptide (35), C-reactive protein (36), astroglial markers GFAP, CHI3L1, and S100B (37), oligodendrocyte marker MBP (37), and IL-6 (14). Here, CHI3L1 is linked to stroke disorder.