Although A2A-R also has been associated with AF (Hove-Madsen et al., 2006; Llach et al., 2011; Molina et al., 2016), the present manuscript focuses on A1-R as the most likely candidate involved in the relation between adenosine and AF (Belardinelli and Isenberg, 1983; Visentin et al., 1990; Kabell et al., 1994; Atienza et al., 2006; Ip et al., 2013; Li et al., 2016). Here, ADORA2A is linked to atrial fibrillation.