The common targets of these SMKIs include vascular endothelial growth factor receptors 1, 2 and 3 (VEGFRs) and platelet-derived growth factor receptor (PDGFR), which are both present in renal cell carcinoma (RCC) (Porta and Schmidinger, 2019). The gene discussed is FLT1; the disease is renal cell carcinoma.