A randomized phase 3 trial, which compared brigatinib versus crizotinib in the treatment for patients with ALK-positive NSCLC, reported that incidence of hypertension was about 23% in the brigatinib 180 mg arm and 7% in the crizotinib 250 mg arm (Camidge et al., 2018). This evidence concerns the gene ALK and non-small cell lung carcinoma.