The TSC1 or TSC2 genes pathogenic changes lead to upregulation of the mechanistic target of rapamycin (mTOR) signal pathway, in charge of synaptic plasticity, protein synthesis, cell growth, proliferation, differentiation, and migration, which has relationship with the formation of benign hamartomas in the brain, heart, liver, kidneys, lungs, skin and retina etc. (van der Poest Clement et al., 2020). The gene discussed is MTOR; the disease is hamartoma.