AGT and cardiac hypertrophy: Several recent investigations have demonstrated that the immunoproteasome catalytic subunits (such as β2i and β5i) and their corresponding proteasome activities were significantly upregulated in the hearts, and exert a critical role in cardiac hypertrophy induced by Ang II infusion or pressure overload (Li et al., 2018; Cao et al., 2019; Xie et al., 2019).