In a before-after self-controlled study, patients with potential metabolic syndrome consuming H2 rich water for 10 weeks resulted in decreased serum TC and LDL-cholesterol levels, and apo B100 and apo E levels, improved dyslipidemia-injured HDL functions, including the ability to inhibit LDL oxidation, the ability to suppress TNF-α-induced monocyte adhesion to endothelial cells (ECs) and TNF-α-induced ECs apoptosis, and the ability to stimulate cholesterol efflux from macrophage foam cells (Song et al., 2013). The gene discussed is TNF; the disease is metabolic syndrome.