INS and Hepatic fibrosis: Through knockdown or knockout (KO) of H2S-generating enzymes in cells or in animals, endogenous H2S has been shown to have essential roles in affecting glucose and lipids metabolism, insulin sensitivity, hepatic oxidative stress, hepatic mitochondrial bioenergetics (modulating mitochondrial structure and function, respiratory chain, and cellular bioenergetics), hepatic fibrosis and autophagy et al. (Mani et al., 2014; Sun et al., 2015; Ci et al., 2017; Wang et al., 2017; Wenzhong et al., 2017; Untereiner and Wu, 2018; Wu et al., 2019).