PCSK1 and ischemic stroke: Here, we present a couple of novel findings: (1) both SB216763 and Nec-1 attenuate ischemic stroke-induced glial scar formation via inhibition of inflammatory cytokines in astrocytes; (2) SB216763 and Nec-1 attenuate inflammatory cytokines by blocking RIP1K or GSK3β activation, and by reducing an interaction between RIP1K and GSK3β during glial scar formation.