Activated astrocytes are dysfunctional, undergo an inflammatory cascade, and abnormally release γ-aminobutyric acid (γ-GABA; Jo et al., 2014), affecting the glutamate cycle (Olabarria et al., 2011), which dysregulates Ca2 + homeostasis and signaling and promotes Aβ deposition and synaptic plasticity damage in APP/PS1 mice in the early stage of AD progression (Gómez-Gonzalo et al., 2017). The gene discussed is APP; the disease is Alzheimer disease.