GFAP and Alzheimer disease: The colocalization of GFAP with Aβ suggested that the mechanism of action of AtDCS in this stage of AD may have two pathways: AtDCS could promote the degradation and clearance of Aβ by activating many glial cells at an early stage; AtDCS may directly affect production and degradation of Aβ, and reduce the number of Aβ deposits, thereby reduce the activation of glial cells.