Both SGIP1 and CB1R are strongly associated with diet-induced obesity [DIO; (Trevaskis et al., 2005; Soria-Gomez et al., 2014; Cardinal et al., 2015)] and siRNA-mediated knockdown of hypothalamic SGIP1 inhibited food intake, suggesting that SGIP1 in the hypothalamus plays a role in energy expenditure (Trevaskis et al., 2005). The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.