Both SGIP1 and CB1R are strongly associated with diet-induced obesity [DIO; (Trevaskis et al., 2005; Soria-Gomez et al., 2014; Cardinal et al., 2015)] and siRNA-mediated knockdown of hypothalamic SGIP1 inhibited food intake, suggesting that SGIP1 in the hypothalamus plays a role in energy expenditure (Trevaskis et al., 2005). This evidence concerns the gene CNR1 and Obesity.