The first mutations reported were those in the gene coding for Cu/Zn superoxide dismutase (SOD1) protein, which account for around 15% of all fALS and 1–2% of the sporadic cases (sporadic ALS or sALS) in European population (Rosen et al., 1993; Stephenson and Amor, 2017; Zou et al., 2017). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.