Hexanucleotide repeats (GGGGCC) in intron 1 of chromosome 9 open reading frame 72 (C9orf72) gene were identified as the major cause of ALS, being present in 30–40% of fALS and 5% of sALS cases in European population (DeJesus-Hernandez et al., 2011; Renton et al., 2011; Majounie et al., 2012; Zou et al., 2017). Here, C9orf72 is linked to amyotrophic lateral sclerosis.