Interestingly, a Mendelian randomization study of the PCSK9 LOF variant rs11591147 (R46L, G/T) in 337,536 individuals from the UK Biobank found the T allele was protective against ischemic stroke in the hypothesis-driven set and a nominally significant association with stroke in the full data set (Rao et al., 2018). This evidence concerns the gene PCSK9 and stroke disorder.