One of the first publications about neuronal death in the high expressor SOD1 mouse model [(SOD1∗G93A)1Gur/J] that is used by most ALS researchers also analyzed neurofilament proteins in the lumbar spinal cord and found reduced neurofilament reactivity caused by a loss of motor neurons and axons (Feeney et al., 2001). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.