Furthermore, observed changes in NF-L levels of GD mice suggest that NF-L might not only be a valuable biomarker in classical neurodegenerative diseases but also in other diseases that have a neuronal component like some lysosomal storage diseases, e.g., GD, Pompe disease, Krabbe disease, or Sanfilippo syndrome. The gene discussed is NEFL; the disease is neurodegenerative disease.