MAPT and tauopathy: Overexpression of human mutant P301S tau in mice under a neuron-specific promoter has previously been shown to recapitulate the core features of tauopathies including progressive neuronal loss, a neuroinflammatory response and accumulation of hyperphosphorylated tau, thus making this model suitable for the evaluation of putative therapeutic strategies (Bellucci et al., 2004, 2011; Sasaki et al., 2008; Hampton et al., 2010; Jucker and Walker, 2011; Holmes et al., 2014; Torvell et al., 2019).