While previous studies have reported the cell-to-cell transmission of TDP-43 (Nonaka et al., 2013; Feiler et al., 2015; Zeineddine et al., 2017; Porta et al., 2018; Laferrière et al., 2019) and aggregation potential (Yang et al., 2010; Zhang et al., 2013; Shimonaka et al., 2016), these studies have not reported the transmissibility of truncated TDP-43, a critical component in the pathogenesis in TDP-43 proteinopathies. The gene discussed is TARDBP; the disease is proteostasis deficiencies.