For example, after removing rs45446698 (located within gene CYP3A7-CYP3AP1 and had the largest maternal effect size on birth weight with beta = 0.077), the OR is estimated to be 1.11 (95% CI 0.99–1.24, p = 0.068); after removing rs139429176 (located within gene P2RX7/HNF1A and had the largest effect size on stroke with beta = −0.155), the OR is estimated to be 1.12 (95% CI 1.00–1.25, p = 0.041). This evidence concerns the gene HNF1A and stroke disorder.