All in all, our work illustrated that LINC01094 contributes to radioresistance development in ccRCC through modulating CHEK2-stabilized FOXM1 by acting as a ceRNA to up-regulate CHEK2, which might open up a new way to overcome the radioresistance in ccRCC. The gene discussed is LINC01094; the disease is nonpapillary renal cell carcinoma.