In the meantime, the level of checkpoint kinase 2 (CHEK2) protein, a pivotal factor involving in DNA damage repair, was verified to be distinctly reduced under irradiated condition and was further downregulated by LINC01094 inhibition (Fig. 2d) Taken together, LINC01094 contributes to radiotolerance in ccRCC via improving DNA DSBs repair. Here, CHEK2 is linked to nonpapillary renal cell carcinoma.