In the meantime, the level of checkpoint kinase 2 (CHEK2) protein, a pivotal factor involving in DNA damage repair, was verified to be distinctly reduced under irradiated condition and was further downregulated by LINC01094 inhibition (Fig. 2d) Taken together, LINC01094 contributes to radiotolerance in ccRCC via improving DNA DSBs repair. The gene discussed is LINC01094; the disease is nonpapillary renal cell carcinoma.