Likewise, in a mouse model of dextran sulfate sodium (DSS)-induced colitis, upon UC-MSC exosome treatment, macrophage infiltration to the tissue was reduced along with downregulation of IL-1β, IL-6, IL-7, TNFα and iNOS in colon tissue and spleen (Mao et al., 2017). The gene discussed is TNF; the disease is colitis.