SPARC and neoplasm: In fact, inhibiting Clever-1-mediated SPARC degradation in neuroblastoma increases chemosensitivity of the tumour to nab-paclitaxel.54 Another Clever-1 ligand, stabilin-1-interacting chitinase-like protein (SI-CLP), inhibits tumour growth in a mouse breast cancer model by blocking the cytokine-induced recruitment of TAMs and altering the cell composition of the TME.55 As the expression of SI-CLP has been reported to be markedly downregulated or absent in some human breast cancers,55 targeting Clever-1 might again prove a worthwhile strategy.