However, when investigating the surface expression of MHC-I (H-2Db and H-2Kb) and PD-L1, the maternal C1498-luc revealed heterogeneous levels of MHC-I and relatively high level of homogenous PD-L1 expression, and these molecules were upregulated in response to inflammatory stimuli IFNγ that could be considered as inflammatory conditions of tumour sites in vivo (Fig. 3g). This evidence concerns the gene IFNG and neoplasm.