Seropositivity for the CagA antigen, however, was associated with hepatobiliary cancer (OR: 1.96; 95% CI: 1.21, 3.18; Table 1), with increased risk of biliary tract cancer (OR: 2.16; 95% CI: 1.03, 4.50) and a similar, though not statistically significant increase in the risk of liver cancer (OR: 1.96; 95% CI: 0.98, 3.93). The gene discussed is S100A8; the disease is biliary tract cancer.